Efficacy of Oritavancin in a Murine Model of Bacillus anthracis Spore Inhalation Anthrax
نویسندگان
چکیده
منابع مشابه
Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax.
The inhaled form of Bacillus anthracis infection may be fatal to humans. The current standard of care for inhalational anthrax postexposure prophylaxis is ciprofloxacin therapy twice daily for 60 days. The potent in vitro activity of oritavancin, a semisynthetic lipoglycopeptide, against B. anthracis (MIC against Ames strain, 0.015 microg/ml) prompted us to test its efficacy in a mouse aerosol-...
متن کاملEfficacy of Daptomycin against Bacillus anthracis in a murine model of anthrax spore inhalation.
Daptomycin demonstrated in vitro (MIC(90), 4 μg/ml) and in vivo activities against Bacillus anthracis. Twice-daily treatment with a dose of 50 mg/kg of body weight was begun 24 h after challenge and continued for 14 or 21 days; results were compared to those for controls treated with phosphate-buffered saline or ciprofloxacin. Day 43 survival rates were 6/10 mice for the 14-day and 9/10 mice fo...
متن کاملCapsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax.
Bacillus anthracis, the agent of anthrax, produces a poly-D-glutamic acid capsule that has been implicated in virulence. Many strains missing pXO2 (96 kb), which harbors the capsule biosynthetic operon capBCAD, but carrying pXO1 (182 kb) that harbors the anthrax toxin genes, are attenuated in animal models. Also, noncapsulated strains are readily phagocytosed by macrophage cell lines, whereas c...
متن کاملAnthrax: Biology of Bacillus anthracis
Perhaps no other microorganism has received as much attention for its use as a potential agent for bioterrorism as Bacillus anthracis. In spite of the fact that the organism has been known for a very long time, limited progress has been made in developing a vaccine or understanding its biochemical and genetic properties. The genus Bacillus includes aerobic bacilli forming heatresistant spores. ...
متن کاملAchieving Consistent Multiple Daily Low-Dose Bacillus anthracis Spore Inhalation Exposures in the Rabbit Model
Repeated low-level exposures to biological agents could occur before or after the remediation of an environmental release. This is especially true for persistent agents such as B. anthracis spores, the causative agent of anthrax. Studies were conducted to examine aerosol methods needed for consistent daily low aerosol concentrations to deliver a low-dose (less than 10(6) colony forming units (C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2008
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00360-08